April 16, 2018Lipids in Health and DiseaseOpen Access

Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice

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Why the study?

Does treadmill exercise training improve intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice?

Structured PICO

Does treadmill exercise training improve intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice?

Population

Male C57BL/6 mice aged 4 weeks, fed a high-fat diet for 6 weeks to induce obesity

Intervention

Treadmill exercise training (40 min/day, 5 days/week for 8 weeks) with continued high-fat diet

Comparator

High-fat diet without exercise training (HF group) and normal diet control (CO group)

Outcome

Intramuscular triglyceride (IMTG) lipolysis sensitivity (measured by PKA, Plin5, p-Plin5, CGI-58, ATGL, and HSL protein levels) and IMTG volumesurrogate

In a high-fat diet-induced obese mouse model, 8 weeks of treadmill exercise decreased intramuscular triglyceride volume by activating lipolysis factors.

Discussion

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Implication

Supports lipolysis activation by exercise in obese mouse models; hypothesis-generating and should not yet change clinical practice.

Cite This Study

Ko et al. (2018) studied this question.

synapsesocial.com/papers/6a89368fb6153083a5deef23 https://doi.org/10.1186/s12944-018-0730-8

View Full Paper

Ask AI

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Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice

Structured PICO

Discussion

Implication

Cite This Study

Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider