Key result
Ovine interventricular septum exhibits softer passive mechanics and lower collagen content than ventricular free walls.
Why the study?
The interventricular septum contributes to the pumping function of both ventricles, but unlike the ventricular wall, its mechanical behavior remains largely unknown.
This ex vivo ovine study demonstrates that the interventricular septum is significantly more compliant and has lower collagen content than the LV and RV free walls, indicating it is biomechanically distinct and should not be modeled merely as part of either ventricular wall.
Answers are grounded in this paper and cite their sources.
Ovine septal tissue is biomechanically distinct from free walls; leaves open translation to human models and interventions.
The interventricular septum contributes to the pumping function of both ventricles. However, unlike the ventricular wall, its mechanical behavior remains largely unknown. To fill the knowledge gap, this study aims to characterize the biaxial and transmural variation of the mechanical properties of the septum and compare it to the free walls of the left and right ventricles (LV/RV). Fresh hearts were obtained from healthy, adult sheep. The septal wall was sliced along the mid-line into two septal sides and compared to the epicardial layers of the LV- and RV-free walls. Biaxial tensile mechanical tests and constitutive modeling were performed to obtain the passive mechanical properties of the LV- and RV-side of the septum and ventricular walls. We found that both sides of the septum were significantly softer than the respective ventricular walls, and that the septum presented significantly less collagen than the ventricular walls. At low strains, we observed the symmetric distribution of the fiber orientations and a similar anisotropic behavior between the LV-side and RV-side of the septum, with a stiffer material property in the longitudinal direction, rather than the circumferential direction. At high strains, both sides showed isotropic behavior. Both septal sides had similar intrinsic elasticity, as evidenced by experimental data and constitutive modeling. These new findings offer important knowledge of the biomechanics of the septum wall, which may deepen the understanding of heart physiology.
No takes yet. Share an insight, caveat, or question.
Nguyen‐Truong et al. (2021) studied Healthy adult ovine myocardium (interventricular septum vs. left and right ventricular free walls) (n=12). Left- and right-ventricular sides of the interventricular septum subjected to ex vivo biaxial tensile mechanical testing and constitutive modeling vs. Epicardial layers of the left and right ventricular free walls was evaluated on Passive biaxial mechanical properties (elastic modulus and anisotropy) and collagen content (p=<0.05). Both sides of the ovine interventricular septum were softer with lower collagen content than their respective ventricular free walls and exhibited low-strain anisotropy.
Synapse has enriched 10 related papers. Consider them for comparative context: