Key result
Pharmacologic prophylaxis within 24 hours of elective colorectal surgery was associated with lower odds of a 90-day composite adverse event (OR 0.64; 95% CI 0.44-0.93).
Why the study?
Does pharmacologic prophylaxis within 24 hours of surgery reduce death, clinically relevant VTE, and composite adverse events in patients undergoing elective colorectal surgery?
Cohort (n=4,195)
Yes
Does pharmacologic prophylaxis within 24 hours of surgery reduce death, clinically relevant VTE, and composite adverse events in patients undergoing elective colorectal surgery?
Odds Ratio: 0.64 (95% CI 0.44–0.93)
Absolute Event Rate: 2.5% vs 4.2%
p-value: p=0.002
Pharmacologic prophylaxis administered within 24 hours of elective colorectal surgery is associated with significantly lower 90-day rates of death, clinically relevant VTE, and composite adverse events.
No takes yet. Share an insight, caveat, or question.
May support early prophylaxis in elective colorectal surgery; hypothesis-generating and requires randomized confirmation before practice change.
Kwon et al. (2011) conducted a cohort in Elective colon/rectal resections (n=4,195). Pharmacologic prophylaxis for VTE within 24 hours of surgery vs. No pharmacologic prophylaxis within 24 hours of surgery was evaluated on Composite adverse event (CAE) at 90 days (OR 0.64, 95% CI 0.44-0.93, p=0.002). Pharmacologic prophylaxis within 24 hours of elective colorectal surgery was associated with lower odds of a 90-day composite adverse event (OR 0.64; 95% CI 0.44-0.93).
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