Hepatic epithelioid hemangioendothelioma can be diagnosed via fine-needle aspiration based on characteristic cytological features, distinguishing it from adenocarcinoma and angiosarcoma.
Case report supports FNA diagnosis of hepatic epithelioid hemangioendothelioma; leaves open validation before clinical adoption.
We present the cytological features of hepatic epithelioid hemangioendothelioma (EH), which is considered to be a vascular proliferation of intermediate malignant potential. The case report concerns a 52-yr-old previously healthy man discovered to have multiple hepatic masses upon evaluation for abnormal liver function tests. Fine-needle aspiration demonstrated a neoplasm composed of interanastomosing epithelioid cells that contained intracytoplasmic lumens. Histologic sections, immunohistochemistry, and ultrastructural evaluation were confirmatory. Although hepatic EH is a rare tumor, its characteristic cytological, histological, and ultrastructural features permit a straightforward diagnosis. It is important to distinguish this entity from adenocarcinoma and angiosarcoma because long-term disease-free survival is possible, especially in the setting of orthotopic liver transplantation.
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Soslow et al. (1997) studied this question.
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