Key result
Obstructive sleep apnea was associated with significantly higher carotid intima-media thickness compared to healthy controls (SMD 0.881; 95% CI 0.647-1.115; P<.001).
Why the study?
Is obstructive sleep apnea associated with increased carotid intima-media thickness compared to healthy controls?
Meta-Analysis
Is obstructive sleep apnea associated with increased carotid intima-media thickness compared to healthy controls?
Standardized Mean Difference: 0.881 (95% CI 0.647–1.115)
p-value: p=<.001
Obstructive sleep apnea is independently associated with increased carotid intima-media thickness, highlighting the importance of cardiovascular screening in this population.
Supports CV screening in OSA; extends observational evidence linking OSA to subclinical atherosclerosis.
Obstructive sleep apnea (OSA) has been suggested as a risk factor for carotid atherosclerosis. The present meta-analysis aimed to evaluate the association between OSA and carotid intima-media thickness (CIMT). Eighteen studies comparing CIMT of patients with OSA versus non-OSA patients were included. Quantitative data synthesis was used to pool weighted standardized difference in means (SMD) of CIMT in a random-effects model. Compared to healthy controls, patients with OSA had a significantly higher CIMT (SMD: 0.881; 95% confidence interval [CI]: 0.647-1.115; P < .001). Due to the great heterogeneity, a subgroup analysis was conducted based on the study design. The pooled SMD of CIMT between patients with OSA and healthy controls were 0.810 (95% CI: 0.676-0.943; P < .001) and 1.008 (95% CI: 0.506-1.510; P < .001) in matched and unmatched group, respectively. Moreover, the correlation of apnea-hypopnea index and CIMT was moderate ( r = .389; 95% CI: 0.315-0.459; P < .001). After adjustment for several major confounders, OSA is an independent risk factor for CIMT. These findings remind clinicians to screen for cardiovascular diseases in patients with OSA.
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Zhou et al. (2016) conducted a meta-analysis in Obstructive sleep apnea. Obstructive sleep apnea vs. Healthy controls / non-OSA patients was evaluated on Carotid intima-media thickness (CIMT) (SMD 0.881, 95% CI 0.647-1.115, p=<.001). Obstructive sleep apnea was associated with significantly higher carotid intima-media thickness compared to healthy controls (SMD 0.881; 95% CI 0.647-1.115; P<.001).
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