The transverse dephasing optimized (TDOP) approach can be used to obtain heteronuclear decoupling sequences that increase significantly coherence lifetimes in solid‐state NMR spectroscopy, leading to a dramatic improvement in the sensitivity of correlation experiments. Herein we demonstrate experimentally on several model organic compounds that, by applying this procedure, solid‐state 13 C‐refocused INADEQUATE experiments are feasible at natural abundance on medium‐sized molecules. Examples are provided for powdered crystalline cholesteryl acetate as well as for a sample of brucine, a less ordered compound. Effects of molecular dynamics on the sensitivity of the experiment are also discussed for a sample of tyrosine ethyl ester.
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Paëpe et al. (2004) studied this question.
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