Answers are grounded in this paper and cite their sources.
Cyclosporin-A (Cyc-A) stimulates prostanoid (PGI2) synthesis in confluent smooth muscle cells from guinea pig aorta through the release of endogenous fatty acid. Cyc-A, like other stimulatory agents for prostanoids, promotes smooth muscle cell proliferation and prostanoid synthesis in these proliferating cells. Indomethacin, a cyclooxygenase inhibitor, and exogenous arachidonic acid block the Cyc-A effect on cell proliferation.
No takes yet. Share an insight, caveat, or question.
Lindsey et al. (1983) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: