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January 1, 1980Endocrinology

Adrenal Regulation of Regional Brain Angiotensinogen Content*

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Why the study?

Does bilateral adrenalectomy and corticosterone replacement alter regional brain and plasma levels of angiotensinogen in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Comparison

Bilateral adrenalectomy and subsequent treatment… vs Sham-operated animals

Design

Preclinical

Follow-up

4 days (for replacement therapy)

Authors

CWCleatus J. WallisUniversity of North TexasMPMorton P. PrintzUniversity of California, San Diego

Discussion

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Implication

Adrenal steroids may regulate brain angiotensinogen in rat cardiovascular centers; leaves open translational relevance to human hypertension or fluid balance.

Key Points

  • To determine how bilateral adrenalectomy and corticosterone replacement therapy alter regional brain and plasma levels of angiotensinogen in male Sprague-Dawley rats.
  • Evaluated male Sprague-Dawley rats subjected to bilateral adrenalectomy or sham surgery, including a subgroup given subcutaneous corticosterone replacement (1 mg/day for 4 days).
  • Measured regional brain neural activity and blood flow using [3H]deoxyglucose accumulation and analyzed tissue angiotensin levels following acid extraction and Dowex 50W×2 chromatography.
  • Adrenalectomy significantly reduced angiotensinogen content in plasma and specific brain regions, including the preoptic area, anterior hypothalamus, periaqueductal grey, and area postrema.
  • Corticosterone replacement reversed the adrenalectomy-induced depletion in all affected regions and increased angiotensinogen content in the septum and mediobasal hypothalamus.
  • Angiotensinogen content did not correlate with [3H]deoxyglucose uptake, vascular supply, blood-brain barrier presence, or ventricular proximity, while endogenous angiotensin I and II were undetectable.

Structured PICO

Does bilateral adrenalectomy and corticosterone replacement alter regional brain and plasma levels of angiotensinogen in male Sprague-Dawley rats?

P
Population
Male Sprague-Dawley rats
I
Intervention
Bilateral adrenalectomy and subsequent treatment with corticosterone (1 mg/day for 4 days, sc)
C
Comparator
Sham-operated animals
O
Outcome
Regional brain and plasma levels of angiotensinogensurrogate

Adrenalectomy reduces and corticosterone replacement restores angiotensinogen levels in specific brain regions associated with cardiovascular and fluid regulation.

Cite This Study

Wallis et al. (1980) studied this question.

synapsesocial.com/papers/6a7d9a680210b8d50ccda269https://doi.org/10.1210/endo-106-1-337
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