This review highlights the crucial roles of cyclic AMP, microRNAs, and gap junctions in regulating renin cell identity, plasticity, and function.
No immediate change to hypertension management; leaves open targeted modulation of cAMP–miRNA–gap junction pathways in renin cells.
PURPOSE OF REVIEW: Renin cells are fundamental for the control of blood pressure, fluid electrolyte homeostasis and kidney development. This review discusses recent discoveries regarding the mechanisms that control the identity and fate of renin cells and their role in the maintenance of kidney architecture and function. RECENT FINDINGS: It is now established that cyclic AMP is a crucial factor for the regulation of the renin phenotype. Furthermore, additional factors such as microRNAs and gap junctions have recently emerged as key regulators for the maintenance and proper functioning of renin cells. SUMMARY: Experiments described in this review will hopefully raise new questions regarding the mechanisms that control the identity, plasticity and function of renin cells.
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Sequeira-Lόpez et al. (2010) studied this question.
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