April 1, 2000British Journal of PharmacologyOpen Access

Compounds that block both intermediate‐conductance (IKCa) and small‐conductance (SKCa) calcium‐activated potassium channels

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Population

Rabbit blood cells (red cells suspended at an haematocrit of 1% or 0.02%)

Design

Preclinical

Authors

MMMisbah Malik‐HallUniversity College London CGC. Robin GanellinUniversity College London DGDimitrios GalanakisInstitute of Geology and Mineral Exploration

Discussion

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Implication

UCL 1407 merits preclinical follow-up as IK(Ca) blocker; hypothesis-generating, with no immediate clinical implications from animal data.

Structured PICO

Population

Rabbit blood cells (red cells suspended at an haematocrit of 1% or 0.02%)

Intervention

Nine bis-quinolinyl and bis-quinolinium compounds related to dequalinium (including UCL 1407, UCL 1440, UCL 1438, and UCL 1684)

Outcome

Inhibitory effects on IK(Ca)-mediated net loss of cell K(+) following the addition of the Ca(2+) ionophore A23187surrogate

The study identifies new intermediate-conductance Ca(2+)-activated K(+) channel blockers, such as UCL 1407, with a wide range of IK(Ca)/SK(Ca) selectivities.

Cite This Study

Malik‐Hall et al. (2000) studied this question.

synapsesocial.com/papers/6a7d9c925d36433ac2186ff1 https://doi.org/10.1038/sj.bjp.0703233

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Compounds that block both intermediate‐conductance (IKCa) and small‐conductance (SKCa) calcium‐activated potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Compounds that block both intermediate‐conductance (IKCa) and small‐conductance (SKCa) calcium‐activated potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider