Population
Isolated Xenopus oocyte nuclei
Design
Preclinical
Authors
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Characterizes nuclear IP3R in native membranes; leaves open its role in cardiac Ca2+ signaling pending intact-cell validation.
This study provides the first characterization of the single-channel properties of the IP3 receptor in its native membrane environment, demonstrating that patch clamp electrophysiology of intact nuclei can directly record these currents.
Mak et al. (1994) studied this question.
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