Key result
Tumor growth in rats with Walker 256/DOX led to less pronounced changes in biochemical parameters, including a 15.5% lower uric acid concentration compared to wild-type Walker 256 carcinosarcoma.
Why the study?
The study was designed to evaluate biochemical blood plasma parameters and internal organ morphology in rats bearing doxorubicin-sensitive versus doxorubicin-resistant Walker 256 carcinosarcoma strains.
Does the doxorubicin-resistant strain of Walker 256 carcinosarcoma cause different biochemical and morphological changes compared to the sensitive strain in rats?
Does the doxorubicin-resistant strain of Walker 256 carcinosarcoma cause different biochemical and morphological changes compared to the sensitive strain in rats?
Answers are grounded in this paper and cite their sources.
Tumor growth in rats with doxorubicin-resistant Walker 256 carcinosarcoma leads to less pronounced biochemical and morphological changes compared to the wild-type strain.
AIM: To evaluate the changes of some biochemical blood plasma parameters and morphological structure of the internal organs of rats with transplanted doxorubicin (DOX)-sensitive (Walker 256) and doxorubicin-resistant (Walker 256/DOX) strains of Walker 256 carcinosarcoma. MATERIALS AND METHODS: day after transplantation of tumor cells, a comparative analysis of some blood plasma biochemical parameters and morphological examination of the liver, kidneys, myocardium and spleen of rats was carried out. RESULTS: Walker 256 growth, in comparison with Walker 256/DOX, is accompanied by more pronounced systemic effect on tumor-bearing rats. Uric acid concentration in the blood plasma of Walker 256 bearing rats was significantly (by 15.5%) higher than in Walker 256/DOX bearing rats. Aspartate aminotransferase activity in the Walker 256 group was significantly (by 107.2%) higher than in Walker 256/DOX group, but alanine aminotransferase activity was 58.5% lower. 56.7% decrease of alkaline phosphatase in rats with Walker 256, and 21% increase of this index in rats with Walker 256/DOX were observed. The growth of Walker 256 carcinosarcoma led to greater structural damage of the liver, kidneys and spleen in experimental animals compared with Walker 256/DOX strain. CONCLUSION: Tumor growth in rats with Walker 256/DOX leads to less pronounced changes in the biochemical parameters of rat blood plasma and morphological structure of internal organs compared with wild-type carcinosarcoma.
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Yushko et al. (2021) studied Walker 256 carcinosarcoma (n=30). Walker 256/DOX carcinosarcoma vs. Walker 256 carcinosarcoma (wild-type) was evaluated on Uric acid concentration (mmol/l) (p=<0.05). Tumor growth in rats with Walker 256/DOX led to less pronounced changes in biochemical parameters, including a 15.5% lower uric acid concentration compared to wild-type Walker 256 carcinosarcoma.
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