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August 15, 2003HeartOpen Access

Severe renal dysfunction (< 30 ml/min) was associated with almost four times higher odds of in-hospital death compared to normal/minimally impaired renal function (OR 3.71, 95% CI 2.57 to 5.37).

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Why the study?

Does reduced creatinine clearance at admission predict hospital mortality and major bleeding in patients with acute coronary syndromes?

Population

11,774 patients hospitalized with acute coronary syndromes, including ST and non-ST segment elevation acute…

Comparison

Moderate or severe renal dysfunction at hospital… vs Normal and minimally impaired renal function

Design

Cohort

Follow-up

in-hospital

Authors

JSJosé Santopinto

Discussion

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Member takes

Overview

May aid ACS risk stratification by admission renal function; leaves open whether targeted interventions improve outcomes.

Structured PICO

Does reduced creatinine clearance at admission predict hospital mortality and major bleeding in patients with acute coronary syndromes?

P
Population
11,774 patients hospitalized with acute coronary syndromes, including ST and non-ST segment elevation acute myocardial infarction and unstable angina
I
Intervention
Moderate (creatinine clearance 30-60 ml/min) or severe (creatinine clearance < 30 ml/min) renal dysfunction at hospital admission
C
Comparator
Normal and minimally impaired renal function (creatinine clearance > 60 ml/min)
O
Outcome
Hospital mortalityhard clinical

Creatinine clearance at admission is a strong, independent predictor of in-hospital mortality and major bleeding in patients with acute coronary syndromes.

Cite This Study

José Santopinto (2003) studied this question.

synapsesocial.com/papers/6a7da01633dcb27c99cb5040https://doi.org/10.1136/heart.89.9.1003
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