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April 1, 1999Journal of General Virology

The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon.

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Population

Cells expressing NS5A from HCV subtype 1b isolates and their chimeric form, challenged with…

Comparison

Expression of NS5A protein vs Cells expressing different NS5A variants

Design

Preclinical

Authors

JSJian SongFujian University of Traditional Chinese MedicineMFMotoko FujiiKobe UniversityFWFei WangShihezi University

Discussion

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Implication

NS5A variants may differentially impair IFN efficacy in HCV; leaves open clinical relevance pending human validation.

Structured PICO

P
Population
Cells expressing NS5A from HCV subtype 1b isolates (HCV-1bJk and M094AJk) and their chimeric form, challenged with encephalomyocarditis virus, vesicular stomatitis virus, or Japanese encephalitis virus
I
Intervention
Expression of NS5A protein (HCV-1bJk, M094AJk, or chimeric)
C
Comparator
Cells expressing different NS5A variants
O
Outcome
Inhibition of interferon-mediated antiviral activitysurrogate

The 49 amino acid sequence including the ISDR in HCV NS5A plays an important role in inhibiting IFN-mediated antiviral activity, which varies depending on the challenge virus.

Cite This Study

Song et al. (1999) studied this question.

synapsesocial.com/papers/6a7da0db629c956ef7ac7c81https://doi.org/10.1099/0022-1317-80-4-879
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutations in the Nonstructural 5A Gene of European Hepatitis C Virus Isolates and Response to Interferon Alfa1997 · 191 citations
  2. 2Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.1990 · 1,198 citations
  3. 3Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A1995 · 280 citations
  4. 4Expression of the hepatitis C virus genome in rat liver after cationic liposome-mediated in vivo gene transfer1995 · 6 citations