What question did this study set out to answer?

To identify the metabolic mechanisms linking mitochondrial dysfunction to central nervous system aging in normal and prematurely aging mouse models.

November 1, 2010Proceedings of the National Academy of Sciences

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

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Authors

JRJaime M. RossUniversity of Rhode Island JÖJohanna ÖbergStockholm University SBStefan BrenéKarolinska Institutet

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Implication

Animal study uncovers elevated brain lactate driven by shifted lactate dehydrogenase ratios in aging mice, indicating its potential as a noninvasive biomarker for central nervous system aging.

Key Points

To identify the metabolic mechanisms linking mitochondrial dysfunction to central nervous system aging in normal and prematurely aging mouse models.
Measured cerebral lactate levels in normally aging and prematurely aging mtDNA mutator mice using proton magnetic resonance spectroscopy and HPLC.
Assessed respiratory chain enzyme competence and analyzed lactate dehydrogenase (LDH) subunit transcription via in situ hybridization.
Separated tetrameric LDH isoenzymes and quantified bidirectional catalytic activity spectrophotometrically.
Brain lactate levels exhibited a twofold increase during aging in both normally aging and prematurely aging mtDNA mutator mice, coinciding with respiratory chain deficiency.
Transcriptional and isoenzyme distributions shifted toward LDH-A dominance over LDH-B, accelerating the metabolic conversion of pyruvate to lactate.

Cite This Study

Ross et al. (2010) studied this question.

synapsesocial.com/papers/6a7da236f980e836411871ce https://doi.org/10.1073/pnas.1008189107

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Implication

Animal study uncovers elevated brain lactate driven by shifted lactate dehydrogenase ratios in aging mice, indicating its potential as a noninvasive biomarker for central nervous system aging.

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Discussion

Member takes

Implication

Key Points

Cite This Study

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Discussion

Member takes

Implication

Key Points

Cite This Study

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