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May 15, 1992Proceedings of the National Academy of SciencesOpen Access

Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin.

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Population

Yeast Saccharomyces cerevisiae (wild-type and act1 mutant) actin filaments

Comparison

Interaction with rabbit skeletal muscle myosin vs Rabbit skeletal muscle actin

Design

Preclinical

Authors

SKStephen J. KronUniversity of ChicagoDDDavid G. DrubinUniversity of California, BerkeleyDBDavid BotsteinLinköping University

Discussion

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Implication

Species-specific actin sliding rates urge caution extrapolating yeast models to mammals; leaves open relevance to human cardiac myosin function.

Structured PICO

P
Population
Yeast Saccharomyces cerevisiae (wild-type and act1 mutant) actin filaments
I
Intervention
Interaction with rabbit skeletal muscle myosin
C
Comparator
Rabbit skeletal muscle actin
O
Outcome
ATP-dependent sliding movement ratesurrogate

Yeast actin filaments exhibit ATP-dependent sliding movement over rabbit muscle myosin, demonstrating evolutionary conservation of actin function.

Cite This Study

Kron et al. (1992) studied this question.

synapsesocial.com/papers/6a7da253cf7e8b32dacb4e4dhttps://doi.org/10.1073/pnas.89.10.4466
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Actin from Saccharomyces cerevisiae1982 · 25 citations
  2. 2Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.1980 · 407 citations
  3. 3Expression of actin in Escherichia coli. Aggregation, solubilization, and functional analysis.1990 · 43 citations
  4. 4Site-directed mutations of Dictyostelium actin: disruption of a negative charge cluster at the N terminus.1991 · 115 citations
  5. 5Subtilisin cleavage of actin inhibits in vitro sliding movement of actin filaments over myosin.1990 · 85 citations