Key result
High dietary AGE intake is linked to ~19% higher odds of abdominal obesity.
Cross-Sectional (n=5,848)
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Metabolic syndrome (MetS) is a complex disorder which has become one of the major public health challenges worldwide. This study was conducted to evaluate the association between dietary advanced glycation end products (AGEs) and risk of MetS and its components. This cross-sectional study was conducted in a representative sample of 5848 adults, aged 19-70 years. Daily consumption of carboxymethyl lysine, a major type of AGEs, was determined using a validated semi-quantitative food frequency questionnaire. Across increasing trend of AGEs consumption, the percentage of fat intake increased and that of carbohydrate significantly decreased (p < 0.001). Subjects in the highest (>10,506 kU/d) compared to the lowest (<6673 kU/d) quartile category of AGEs had higher risk of abdominal obesity (OR: 1.19, 95% CI: 1.01-1.39) and hypertriglyceridemia (OR: 1.26, 95% CI: 1.07-1.49). Therefore, recommendation on restriction of AGEs intake could be a practical approach to prevent metabolic abnormalities.
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Angoorani et al. (2016) conducted a cross-sectional in Metabolic syndrome (n=5,848). Dietary consumption of advanced glycation end products (carboxymethyl lysine, highest quartile >10,506 kU/d) vs. Lowest quartile of dietary AGEs consumption (<6673 kU/d) was evaluated on Risk of metabolic syndrome and its components (abdominal obesity and hypertriglyceridemia) (OR 1.19, 95% CI 1.01-1.39). High dietary AGE consumption (>10,506 vs <6673 kU/d) was associated with higher odds of abdominal obesity and hypertriglyceridemia.
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