Key result
The p.Y1449C SCN5A mutation was associated with an overlap syndrome comprising conduction disease, Brugada syndrome, and atrial arrhythmias in a single family.
Case Report
Identifies a novel association between the p.Y1449C SCN5A mutation and a complex overlap arrhythmia syndrome comprising conduction disease, Brugada syndrome, and atrial flutter.
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May inform SCN5A testing in arrhythmia overlap syndromes; leaves open pathogenicity of p.Y1449C pending validation.
Mutations in the SCN5A gene, which encodes the cardiac sodium channel, have been associated with cardiac arrhythmia syndromes and conduction disease. Specific SCN5A mutations had initially been considered to cause specific phenotypes. More recently, some SCN5A mutations have been associated with overlap syndromes, characterized by phenotypic heterogeneity within and between mutation carriers. Here we report and associate the presence of the p.Y1449C SCN5A mutation in a single family with a spectrum of cardiac phenotypes including conduction disease, Brugada syndrome and atrial arrhythmias, for the first time to our knowledge.
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Hothi et al. (2014) conducted a case report in Conduction disease, Brugada syndrome, and atrial arrhythmias. p.Y1449C SCN5A mutation was evaluated on Cardiac phenotypes. The p.Y1449C SCN5A mutation was associated with an overlap syndrome comprising conduction disease, Brugada syndrome, and atrial arrhythmias in a single family.
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