Key result
High Lp(a) is linked to a ~7% increase in factor V coagulant activity.
Why the study?
Although a prothrombotic diathesis has been proposed as a mechanism linking Lp(a) to cardiovascular disease, the relationship between Lp(a) and coagulation remains controversial.
Population
384 clinically stable subjects undergoing elective coronary angiography
Comparison
Lp(a) levels: normal (<30 mg/dL) vs intermediate (30-50 mg/dL) vs high (>50 mg/dL)
Design
Cohort study
Authors
Loading...
Mild Factor V link does not support Lp(a)-guided coagulation assessment; leaves open larger effects in prospective studies.
Cohort (n=384)
Effect estimate: standardized beta coefficient 0.101
Absolute Event Rate: 90.1% vs 84.3%
p-value: p=0.010
Lp(a) plasma levels do not appear to majorly modulate the coagulation phenotype in cardiovascular patients, showing only a mild independent association with Factor V coagulant activity.
Osti et al. (2025) conducted a cohort in Coronary artery disease (n=384). Lipoprotein(a) plasma levels vs. Low Lipoprotein(a) plasma levels was evaluated on Coagulant activity of factor V (FV:C) (standardized beta coefficient 0.101, p=0.010). High Lipoprotein(a) plasma levels were associated with a mild increase in factor V coagulant activity compared to low levels (90.1% vs 84.3%; P=0.010), with no major effect on other coagulation biomarkers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: