Key result
A CHA2DS2-VASc score ≥3 predicted unsuccessful endovascular intervention in acute ischemic stroke patients with 76.6% sensitivity and 83.3% specificity (AUC 0.827; 95% CI 0.739-0.895; P<0.001).
Why the study?
Endovascular procedure success correlates with clinical outcomes in acute ischemic stroke, but the relationship between the CHA2DS2-VASc score and procedure success in these patients was unclear.
Does the CHA2DS2-VASc score predict successful endovascular treatment in patients with acute ischemic stroke?
Observational (n=102)
Does the CHA2DS2-VASc score predict successful endovascular treatment in patients with acute ischemic stroke?
A higher admission CHA2DS2-VASc score (≥3) is an independent predictor of unsuccessful percutaneous endovascular intervention in patients with acute ischemic stroke.
May identify stroke patients at risk for unsuccessful EVT; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVES: Acute ischemic stroke is a common cause of mortality and morbidity worldwide. Percutaneous endovascular intervention is an important treatment method in ischemic stroke. Endovascular procedure success is associated with the clinical outcome of the patients. The CHA2DS2-VASC score is an important score used to determine the risk of ischemic stroke in patients with atrial fibrillation. In our study, we aimed to evaluate the relationship between procedure success and CHA2DS2-VASC score in patients with acute ischemic stroke who underwent endovascular intervention. MATERIALS AND METHODS: A total of 102 consecutive patients who underwent endovascular intervention with acute ischemic stroke were included in the study. The admission CHA2DS2-VASc scores of the patients were recorded. After the procedure, the relationship between the TICI score and the CHA2DS2-VASc score was evaluated. RESULTS: CHA2DS2-VASc score was significantly higher in the group that resulted in unsuccessful endovascular intervention (2.78 ± 1.44, 5.02 ± 1.77 p < .001). Receiver-operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score ≥3 as a predictor of unsuccessful intervention with 76,6% sensitivity and 83,3% specificity, positive predictive value 50%, negative predictive value 84,6% (area under the curve [AUC]: 0.827,95% CI: 0.739-0.895, p < .001). In the multivariate analysis; atrial fibrillation ([β] = 4.201; [CI]: 1.251-14.103, p = .020), CHA2DS2-VASc score ([β] = 0.053; [CI]: 0.004-0.750, p = .030) were found independent predictors for unsuccessful intervention treatment. CONCLUSIONS: In our study, we showed that the CHA2DS2-VASc score is associated with the success of endovascular intervention in patients with acute ischemic stroke who underwent percutaneous endovascular treatment.
No takes yet. Share an insight, caveat, or question.
Yaşar et al. (2021) conducted an observational in Acute ischemic stroke (n=102). CHA2DS2-VASc score was evaluated on Unsuccessful endovascular intervention (β 0.053, 95% CI 0.004-0.750, p=.030). A CHA2DS2-VASc score ≥3 predicted unsuccessful endovascular intervention in acute ischemic stroke patients with 76.6% sensitivity and 83.3% specificity (AUC 0.827; 95% CI 0.739-0.895; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: