June 1, 2000Journal of Clinical MicrobiologyOpen Access

Molecular Characterization of Campylobacter jejuni from Patients with Guillain-Barre and Miller Fisher Syndromes

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Population

18 GBS- or MFS-related Campylobacter jejuni strains and 17 control strains from The Netherlands and Belgium

Comparison

Molecular characterization including serotyping… vs 17 control strains

Design

Preclinical

Authors

HEHubert P. EndtzErasmus MC CAC. Wim AngNueva Ecija University of Science and Technology NBNicole van den BraakUniversitätsklinikum Aachen

Discussion

Member takes

Implication

Absence of distinguishing markers advises against relying on current typing for GBS risk stratification; leaves open identification of novel virulence determinants.

Structured PICO

Population

18 GBS- or MFS-related Campylobacter jejuni strains and 17 control strains from The Netherlands and Belgium

Intervention

Molecular characterization including serotyping (Penner and Lior), restriction fragment length polymorphism (RFLP) analysis of PCR products of the flaA gene, amplified fragment length polymorphism (AFLP) analysis, pulsed-field gel electrophoresis (PFGE), and randomly amplified polymorphic DNA (RAPD) analysis

Comparator

17 control strains (non-GBS- or non-MFS-related enteritis strains)

Outcome

Clonality and clustering of strains

There is substantial molecular heterogeneity among C. jejuni strains associated with GBS and MFS, indicating that specific molecular markers for these pathogenic strains remain unidentified by standard typing methods.

Cite This Study

Endtz et al. (2000) studied this question.

synapsesocial.com/papers/6a7da816968fa26fcacb4cef https://doi.org/10.1128/jcm.38.6.2297-2301.2000

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Implication

Absence of distinguishing markers advises against relying on current typing for GBS risk stratification; leaves open identification of novel virulence determinants.

Molecular Characterization of Campylobacter jejuni from Patients with Guillain-Barre and Miller Fisher Syndromes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Characterization of Campylobacter jejuni from Patients with Guillain-Barre and Miller Fisher Syndromes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider