The impact of MRI findings in the liver in the diagnosis of pediatric Wilson’s disease

Güleç Mert Doğan; Şükrü Güngör; Gökalp Okut; Fatma İlknur Varol; Ahmet Sığırcı; Sezai Yılmaz

doi:10.28982/josam.951931

October 1, 2021Journal of Surgery and MedicineOpen Access

The impact of MRI findings in the liver in the diagnosis of pediatric Wilson’s disease

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Key Points

Characterize qualitative and quantitative liver MRI features in pediatric Wilson disease and assess their correlation with serum ceruloplasmin and 24-hour urinary copper levels.
Cohort study of 35 pediatric patients with Wilson disease younger than 18 years old.
Evaluated qualitative MRI parameters (parenchymal nodules, contour irregularity, honeycomb pattern, ascites, periportal thickness) and quantitative parameters (splenomegaly, caudate lobe to right lobe ratio).
Correlated imaging parameters with serum ceruloplasmin and 24-hour urinary copper scored via the 2001 Leipzig diagnostic criteria.
Splenomegaly and ascites were the most prevalent MRI findings, occurring in 19 (52.7%) and 17 (48.6%) patients, respectively, whereas 28 (80%) exhibited a normal caudate-to-right-lobe ratio.
Serum ceruloplasmin levels were significantly lower in patients displaying parenchymal nodules, irregular liver contours, ascites, increased periportal thickness, or splenomegaly compared to those without these findings.

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Implication

Cohort study reveals distinct hepatic MRI abnormalities correlate with lower ceruloplasmin in pediatric Wilson disease, highlighting imaging's diagnostic value.

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Cite This Study

Doğan et al. (2021) studied this question.

synapsesocial.com/papers/6a7da8d1fa78bd2571186beb https://doi.org/10.28982/josam.951931

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The impact of MRI findings in the liver in the diagnosis of pediatric Wilson’s disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The impact of MRI findings in the liver in the diagnosis of pediatric Wilson’s disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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