Key result
Estimating GFR using cystatin C eliminated the negative consequences of race-based approaches and avoided systematic misclassification seen with serum creatinine without race.
Why the study?
The inclusion of race in equations to estimate GFR has become controversial, and alternative equations achieving similar accuracy without race are needed.
Does estimating GFR with cystatin C improve accuracy without using race compared to serum creatinine in adults with chronic kidney disease?
Population
1248 adults with chronic kidney disease
Comparison
Estimating GFR using cystatin C vs serum creatinine without race or genetic ancestry
Design
Cross-sectional analysis
Loading...
Cystatin C eGFR may avoid race bias without misclassification in CKD; hypothesis-generating pending prospective outcome validation.
Cross-Sectional (n=1,248)
Yes
Does estimating GFR with cystatin C improve accuracy without using race compared to serum creatinine in adults with chronic kidney disease?
Estimating GFR using cystatin C eliminates the need for race-based equations while avoiding the systematic misclassification introduced by using serum creatinine without race.
A 2021 study conducted a cross-sectional in chronic kidney disease (n=1,248). Cystatin C for GFR estimation vs. Serum creatinine for GFR estimation without race was evaluated on GFR estimates in Black participants (95% CI 34-49). Estimating GFR using cystatin C eliminated the negative consequences of race-based approaches and avoided systematic misclassification seen with serum creatinine without race.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: