July 1, 1990The Journal of Pathology

QBEnd/10: A new immunostain for the routine diagnosis of Kaposi's sarcoma

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Why the study?

Does immunostaining with QBEnd/10 improve the diagnosis of Kaposi's sarcoma compared to UEA-1 and FVIIIRAg?

Population

60 skin tumour samples

Comparison

Immunostaining with QBEnd/10 on routine… vs Immunostaining with Ulex europaeus agglutinin 1…

Design

Cohort

Authors

ESElizabeth A. SankeyPilgrim Hospital LMLinda MoreMethodist Hospital ADAmar P. DhillonRoyal Free London NHS Foundation Trust

Discussion

Member takes

Implication

QBEnd/10 may aid Kaposi's sarcoma distinction in routine tissue; leaves open prospective validation against current panels.

Structured PICO

Does immunostaining with QBEnd/10 improve the diagnosis of Kaposi's sarcoma compared to UEA-1 and FVIIIRAg?

Population

60 skin tumour samples (22 Kaposi's sarcomas including patch, plaque, and nodular lesions, and 38 other vascular and spindle cell tumours from skin)

Intervention

Immunostaining with QBEnd/10 (IgG1 mouse monoclonal antibody against human placental endothelial cells) on routine formalin-fixed, paraffin-embedded tissue

Comparator

Immunostaining with Ulex europaeus agglutinin 1 (UEA-1) and factor VIII-related antigen (FVIIIRAg)

Outcome

Clear immunostaining of spindle cells to distinguish Kaposi's sarcoma from other spindle cell neoplasmssurrogate

QBEnd/10 is a useful immunostain for distinguishing Kaposi's sarcoma from other spindle cell neoplasms in routinely processed tissue.

Cite This Study

Sankey et al. (1990) studied this question.

synapsesocial.com/papers/6a7da91ee2054cbe43b8690e https://doi.org/10.1002/path.1711610315

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QBEnd/10: A new immunostain for the routine diagnosis of Kaposi's sarcoma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

QBEnd/10: A new immunostain for the routine diagnosis of Kaposi's sarcoma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider