Key result
Multiplex kinase signaling modifies cardiac function through phosphorylation of sarcomeric proteins, playing a critical role in beat-to-beat regulation and maladaptive remodeling in heart failure.
Design
Review
Authors
Loading...
May guide kinase-targeted therapies in heart failure; leaves open prospective clinical validation.
This review highlights the complex, multiplexed role of kinase signaling in modifying sarcomeric proteins to regulate cardiac myocyte contraction and relaxation on a beat-to-beat basis.
R. John Solaro (2008) conducted a review in Heart failure. Multiplex kinase signaling was evaluated. Multiplex kinase signaling modifies cardiac function through phosphorylation of sarcomeric proteins, playing a critical role in beat-to-beat regulation and maladaptive remodeling in heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: