Key result
Restrictive mitral annuloplasty significantly decreased LV end-diastolic volume index from 151 to 131 mL/m2 (P=0.0001) and improved LV ejection fraction from 27% to 33% (P=0.0007).
Why the study?
Does restrictive mitral annuloplasty improve left ventricular volumes, ejection fraction, and wall stress in patients with dilated cardiomyopathy and functional mitral regurgitation?
Observational (n=24)
Does restrictive mitral annuloplasty improve left ventricular volumes, ejection fraction, and wall stress in patients with dilated cardiomyopathy and functional mitral regurgitation?
Absolute Event Rate: 131% vs 151%
p-value: p=0.0001
Restrictive mitral annuloplasty in patients with dilated cardiomyopathy reduces volume overload and afterload, which correlates with postoperative reverse left ventricular remodeling and improved ejection fraction.
No takes yet. Share an insight, caveat, or question.
May support reverse remodeling in functional MR; hypothesis-generating and requires randomized confirmation before practice change.
Takeda et al. (2010) conducted an observational in Dilated cardiomyopathy and functional mitral regurgitation (n=24). Restrictive mitral annuloplasty vs. Preoperative baseline was evaluated on Left ventricular end-diastolic volume index (LVEDVI) (p=0.0001). Restrictive mitral annuloplasty significantly decreased LV end-diastolic volume index from 151 to 131 mL/m2 (P=0.0001) and improved LV ejection fraction from 27% to 33% (P=0.0007).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: