Key result
Patients with comorbid COPD and arterial hypertension demonstrated pronounced microcirculatory maladjustment, with only a 1.7% increase in blood flow at 1 minute after occlusive stimuli compared to 19.2% in healthy volunteers.
Why the study?
The study was conducted to evaluate the dynamics of microcirculation indices in patients with arterial hypertension, chronic obstructive pulmonary disease, and their combination.
Cross-Sectional (n=226)
No
Absolute Event Rate: 1.7% vs 19.2%
p-value: p=<0.05
Microcirculatory impairment may heighten risk in COPD-hypertension comorbidity; leaves open whether assessment or targeted therapy improves outcomes.
Objective : to study the dynamics of microcirculation indices in patients with arterial hypertension, chronic obstructive pulmonary disease, and in their combination. Material and methods : the study included 226 people, of which 66 people were patients with chronic obstructive pulmonary disease, 54 patients with arterial hypertension, 74 people with a combination of chronic obstructive pulmonary disease and arterial hypertension, 32 relatively healthy volunteers. To assess the circulatory bed, we used a computerized ultrasonic Doppler instrument Minimax-Doppler-K, LLC JV «Minimax». Results : in patients with COPD and AH, microcirculation maladjustment is observed, manifested by a paradoxical reaction to stimuli in the form of an indirect occlusive effect. When studying the correlations between the indicators of the microvasculature and clinical and instrumental data, it was found that there is a relationship between the linear velocities of the microvasculature and the age, the smoking index, systolic blood pressure, pulse blood pressure. A correlation relationship was established between the FEV1 and the maximum linear systolic velocity along the maximum velocity curve in patients with COPD and COPD and AH. Conclusion : COPD and hypertension are comorbid conditions that lead to more pronounced microcirculatory changes, which can have a mutual effect on the course of these diseases.
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Глова et al. (2022) conducted a cross-sectional in Chronic obstructive pulmonary disease and arterial hypertension (n=226). Comorbid COPD and arterial hypertension vs. Healthy volunteers, COPD alone, or arterial hypertension alone was evaluated on Increase in blood flow at 1 minute after occlusive stimuli (p=<0.05). Patients with comorbid COPD and arterial hypertension demonstrated pronounced microcirculatory maladjustment, with only a 1.7% increase in blood flow at 1 minute after occlusive stimuli compared to 19.2% in healthy volunteers.
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