Key result
Dendritic cells drive early atherosclerosis progression and may promote plaque destabilization.
Why the study?
The role and clinical relevance of dendritic cells in atherosclerosis have been increasingly recognized but require summarization and clarification.
This review highlights the emerging understanding of dendritic cells as key players in the immune response and plaque destabilization during atherosclerosis.
DCs central to early atherosclerosis; leaves open therapeutic targeting pending human trials.
Dendritic cells (DCs) are the most potent antigen-presenting cells. DCs were identified in arteries in 1995 and, since then, further knowledge has been gained indicating the importance of DCs in atherosclerosis. Vascular DCs have been shown to become activated from a very early stage of atherosclerosis. Some DCs cluster with T cells directly within atherosclerotic lesions, while others migrate to lymphoid organs to activate T cells. Dyslipidaemia systemically alters DC function and recent findings suggest that DCs play a role in plaque destabilization. This review summarizes the current status of the problem.
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Yuri V. Bobryshev (2005) conducted a review in Atherosclerosis. Dendritic cells was evaluated. Dendritic cells play an important role in atherosclerosis, becoming activated early in the disease process and potentially contributing to plaque destabilization.
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