Why the study?
What are the current and emerging treatment options for end-stage heart failure?
What are the current and emerging treatment options for end-stage heart failure?
Comprehensive heart failure centers are essential to translate evidence-based medical, device, and surgical therapies into effective clinical practice for end-stage heart failure.
May inform multidisciplinary HF center models; extends prior syntheses but leaves optimal implementation of emerging therapies unresolved.
Randomized clinical trials have established the roles of angiotensin-converting enzyme inhibitors, beta-blockers, spironolactone, mechanical circulatory support devices and defibrillators in advanced heart failure. Observational data support the use of cardiac surgical interventions, including revascularization, mitral valve repair, left ventricular geometry restoration, re synchronization therapy and cardiac transplantation. The potential of gene therapy, cell transplantation and xenotransplantation is actively being explored. Comprehensive heart failure centres with expertise in all aspects of medical and surgical advanced heart failure care are evolving, and aim to translate evidence-based management protocols into effective clinical practice.
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Deng et al. (2002) studied this question.
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