Key result
Chemical modifications of anthracyclines, particularly at the amino group, result in altered biological activity that influences both antitumor efficacy and associated cardiotoxicity.
Design
Review
Authors
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May guide development of less cardiotoxic anthracycline analogs; leaves open need for prospective clinical validation.
Chemical modifications of anthracyclines offer pathways to alter their biological activity, potentially impacting their antitumor efficacy and associated cardiotoxicity.
А. В. Семаков (2024) reported a review. Chemical modification of anthracyclines was evaluated. Chemical modifications of anthracyclines, particularly at the amino group, result in altered biological activity that influences both antitumor efficacy and associated cardiotoxicity.
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