Key result
Biophysical and mutational studies revealed that the competitive inhibitor RNA forms a loop-loop interaction and a less stable fold that accommodates ribosome translocation while inhibiting RNase L.
The structural features of the poliovirus ciRNA, including a loop-loop interaction and less stable folding, may allow it to function as an RNase L inhibitor while accommodating ribosome and polymerase translocation.
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May guide RNase L inhibitor design for viral infections; leaves open translation to human cardiac disease.
Keel et al. (2011) studied this question. Competitive inhibitor RNA (ciRNA) was evaluated on Structural architecture and folding of ciRNA. Biophysical and mutational studies revealed that the competitive inhibitor RNA forms a loop-loop interaction and a less stable fold that accommodates ribosome translocation while inhibiting RNase L.
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