Population
Purified RNase L, purified 2-5A, and an RNA substrate with a 5' fluorophore and 3' quencher
Design
Preclinical
Authors
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Supports enteroviral evasion of RNase L in animal models; leaves open relevance to human disease and therapy.
Group C enterovirus RNA competitively inhibits the endoribonuclease domain of RNase L, revealing a mechanism of viral evasion of the interferon-regulated antiviral pathway.
Townsend et al. (2008) studied this question.
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