Why the study?
Does the addition of propafenone to metoprolol alter the pharmacokinetics and plasma concentrations of metoprolol in patients and healthy volunteers?
Does the addition of propafenone to metoprolol alter the pharmacokinetics and plasma concentrations of metoprolol in patients and healthy volunteers?
Propafenone significantly increases metoprolol plasma concentrations, indicating that the dose of metoprolol should be reduced when the two drugs are co-administered.
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Supports cautious metoprolol dose adjustment with propafenone; leaves open validation in prospective clinical studies.
Wagner et al. (1987) studied this question.
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