Key result
Liver cirrhosis was associated with significantly higher serum NT-proBNP levels compared to healthy controls (161.87 vs 87.29 pg/ml) and correlated with the severity of liver dysfunction.
Why the study?
Does serum NT-proBNP correlate with cardiac dysfunction and liver function in patients with liver cirrhosis?
Observational (n=61)
No
Does serum NT-proBNP correlate with cardiac dysfunction and liver function in patients with liver cirrhosis?
Absolute Event Rate: 161.87% vs 87.29%
p-value: p=<0.001
Elevated serum NT-proBNP in cirrhotic patients correlates with the severity of liver disease and echocardiographic signs of diastolic dysfunction, supporting its use as a marker for cirrhotic cardiomyopathy.
NT-proBNP may mark cirrhotic cardiomyopathy; hypothesis-generating and should not yet change practice.
Objective To detect the values of NT-proBNP and evaluate its relationship with liver function, cardiac structure, and cardiac function which was evaluated by echocardiography in patients with liver cirrhosis. Methods A total of 50 liver cirrhotic patients and 11 healthy controls were studied by two dimensional Doppler echocardiography. Liver cirrhotic patients were divided into group A, B and C according to the Child-Pugh score. Cardiac dimensions and left and right ventricular functions were also evaluated. At the same time, the serum NTproBNP of liver cirrhotic patients and healthy controls were detected, respectively. Results By Comparison between two groups, we found that the values of LVd, LAs, LVPW, AAO, A Wave, RVOTs, PV and NT-proBNP in liver cirrhosis group were higher than those in control group, whereas the value of E/A decreased. As for the value of LAs and serum NT-proBNP, A and B group were all lower than C group. With LAs > 35 mm, the number of cases in liver cirrhosis group was higher than that in control group. So did that With E/A < 1. Conclusions The cardiac dysfunction confirmed the existence of cirrhotic cardiomyopathy. More clinical implications were found in liver cirrhotic patients with increased values of serum NT-proBNP.
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Mao et al. (2013) conducted an observational in Liver cirrhosis (n=61). Liver cirrhosis vs. Healthy controls was evaluated on Serum NT-proBNP levels (pg/ml) (p=<0.001). Liver cirrhosis was associated with significantly higher serum NT-proBNP levels compared to healthy controls (161.87 vs 87.29 pg/ml) and correlated with the severity of liver dysfunction.
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