February 26, 2001Archives of Internal Medicine
Aspirin and Angiotensin-Converting Enzyme Inhibitors Among Elderly Survivors of Hospitalization for an Acute Myocardial Infarction
Why the study?
Does the combination of aspirin and ACE inhibitors reduce 1-year mortality in elderly survivors of acute myocardial infarction compared to either therapy alone or neither?
Population
14,129 elderly patients who survived hospitalization with a confirmed acute myocardial infarction and were…
Comparison
Combination of aspirin and ACE inhibitors at… vs Aspirin only, ACE inhibitors only, or neither at…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports combined aspirin-ACE inhibitor use post-MI without evident interaction; leaves open additive benefit versus monotherapy pending randomized trials.
Structured PICO
Does the combination of aspirin and ACE inhibitors reduce 1-year mortality in elderly survivors of acute myocardial infarction compared to either therapy alone or neither?
P
Population
14,129 elderly patients (aged 65 years and older) who survived hospitalization with a confirmed acute myocardial infarction (AMI) and were ideal candidates for the therapies.
I
Intervention
Combination of aspirin and ACE inhibitors at discharge
C
Comparator
Aspirin only, ACE inhibitors only, or neither at discharge
O
Outcome
1-year mortalityhard clinical
The combination of aspirin and ACE inhibitors post-AMI in elderly patients provides a mortality benefit consistent with either therapy alone, without evidence of a clinically significant negative interaction.
Cite This Study
Krumholz et al. (2001) studied this question.