eNOS variants in the promoter region and exon 7 decrease platelet-derived NO, and estradiol increases platelet aggregation in individuals homozygous for the exon 7 variant, suggesting a genetic influence on thrombotic response.
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eNOS variants may modulate estrogen effects on platelets; hypothesis-generating in animal models only.
Tanus‐Santos et al. (2002) studied this question.
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