Differential Scanning Calorimetry Evaluation and Orthogonal Projection to Latent Structure Prediction of Thermal Hazards Associated with Five-Membered Aromatic Heterocycles with at Least Two Heteroatoms

Integration of advanced calorimetric techniques and multivariate analysis software underscores the importance of combining experimental precision with robust analytical tools. In this study, thermal hazards of five-membered aromatic heterocycles with at least two heteroatoms were systematically evaluated using differential scanning calorimetry. The experimental data were used to develop orthogonal projection to latent structure models for predicting potential thermal hazards of these compounds, which provided accurate correlations between experimental data and known thermal behaviors, warranting their application in forecasting onset temperatures and enthalpies of decomposition. These predictive capabilities are crucial tools for understanding thermal hazards and helping to develop mitigating strategies for handling reactive chemicals.