What question did this study set out to answer?

To determine whether heat-induced trans isomers of alpha-linolenic acid are converted and incorporated into long-chain polyunsaturated fatty acid-rich structures in the brain and retina.

April 1, 1994Lipids

Incorporation oftrans long‐chain n−3 polyunsaturated fatty acids in rat brain structures and retina

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Authors

AGA. GrandgirardKlinikum Lippe JBJ.M. BourreDélégation Paris 5 FJF. JulliardCentre de recherche Translationnelle en Médecine moléculaire

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Implication

Animal study reveals trans isomers of omega-3 fatty acids accumulate in rat brain and retinal tissues, indicating dietary heat-altered fats cross into neural membranes.

Key Points

To determine whether heat-induced trans isomers of alpha-linolenic acid are converted and incorporated into long-chain polyunsaturated fatty acid-rich structures in the brain and retina.
Fed female rats diets containing two fractions enriched in trans isomers of alpha-linolenic acid during gestation and lactation.
Harvested synaptosomes, brain microvessels, myelin, sciatic nerve, and retina from weaned pups to quantify fatty acid profiles.
Trans isomers of docosahexaenoic acid (22:6 trans) incorporated at approximately 0.5% of total fatty acids in synaptosomes, brain microvessels, and retina, compared to approximately 0.1% in myelin and sciatic nerve.
Dietary alpha-linolenic acid deficiency doubled the incorporation of trans isomers into neural tissues, while cis isomers were more efficiently elongated and desaturated than trans isomers, elevating 22:5n-6 levels.

Cite This Study

Grandgirard et al. (1994) studied this question.

synapsesocial.com/papers/6a7dbc761cf250867fa13cb5 https://doi.org/10.1007/bf02536329

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Implication

Animal study reveals trans isomers of omega-3 fatty acids accumulate in rat brain and retinal tissues, indicating dietary heat-altered fats cross into neural membranes.

Incorporation oftrans long‐chain n−3 polyunsaturated fatty acids in rat brain structures and retina

Discussion

Member takes

Implication

Key Points

Cite This Study

Incorporation oftrans long‐chain n−3 polyunsaturated fatty acids in rat brain structures and retina

Discussion

Member takes

Implication

Key Points

Cite This Study

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