Key result
Regular aerobic exercise reduced endothelial cortical stiffness in aortic explants compared to sedentary conditions in Western diet-fed female mice (5.5 vs 11.9 kPa; P<0.05).
Why the study?
Does regular aerobic exercise reduce endothelial cortical stiffness in Western diet-fed female mice?
Population
13 four-week-old female C57BL/6 mice fed a Western diet
Comparison
Regular aerobic exercise for 16 weeks vs Sedentary condition (cage confined) for 16 weeks
Design
Preclinical, randomized
Follow-up
16 weeks
Authors
Loading...
No direct clinical implications from this mouse model; leaves open translation of exercise effects on endothelial stiffness to human hypertension.
RCT (n=13)
randomized
Does regular aerobic exercise reduce endothelial cortical stiffness in Western diet-fed female mice?
Absolute Event Rate: 5.5% vs 11.9%
p-value: p=<0.05
Regular aerobic exercise reduces aortic endothelial cortical stiffness and peripheral muscular artery stiffness in Western diet-fed female mice, demonstrating endothelial plasticity.
Padilla et al. (2016) conducted an RCT in Western diet-fed (n=13). Regular aerobic exercise vs. Sedentary was evaluated on Endothelial cortical stiffness in aortic explants (p=<0.05). Regular aerobic exercise reduced endothelial cortical stiffness in aortic explants compared to sedentary conditions in Western diet-fed female mice (5.5 vs 11.9 kPa; P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: