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December 27, 2016Annals of Laboratory MedicineOpen Access

Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting Short-Term Mortality for Patients Presenting to the Emergency Department With Chest Pain

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Key result

In patients presenting to the emergency department with chest pain, sST2 levels at arrival showed higher independent predictive power for short-term mortality than hs-cTnI (OR 20.13, P<0.0001).

Why the study?

Does sST2 have greater prognostic value than hs-cTnI for predicting short-term mortality in patients presenting to the ED with chest pain?

Population

157 patients admitted to the Emergency Department for chest pain at arrival (37% diagnosed with ACS).

Comparison

Soluble ST2 (sST2) measurement at ED arrival vs High-sensitivity cardiac troponin I measurement…

Design

Cohort

Follow-up

30-day

Authors

RMRossella MarinoAzienda Ospedaliera Sant'AndreaLML. MagriniArcetri Astrophysical ObservatoryFOFrancesca OrsiniMurdoch Children's Research Institute

Discussion

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Implication

Should not yet alter ED triage; leaves open prospective validation of sST2 integration with hs-cTnI.

Study Design

Type

Cohort (n=157)

Structured PICO

Does sST2 have greater prognostic value than hs-cTnI for predicting short-term mortality in patients presenting to the ED with chest pain?

P
Population
157 patients admitted to the Emergency Department for chest pain, followed for 30 days to assess mortality.
E
Exposure
Soluble ST2 (sST2) measurement at ED arrival
C
Comparator
High-sensitivity cardiac troponin I (hs-cTnI) measurement at ED arrival
O
Outcome
In-hospital and 30-day follow-up mortalitieshard clinical

Main Result

Odds Ratio: 20.13

p-value: p=<0.0001

sST2 measured at ED arrival provides greater prognostic value for 30-day cardiac mortality than hs-cTnI in patients presenting with chest pain, particularly in those with STEMI.

Cite This Study

Marino et al. (2016) conducted a cohort in Chest pain (n=157). sST2 level at arrival vs. hs-cTnI level at arrival was evaluated on In-hospital and 30-day follow-up mortality (OR 20.13, p=<0.0001). In patients presenting to the emergency department with chest pain, sST2 levels at arrival showed higher independent predictive power for short-term mortality than hs-cTnI (OR 20.13, P<0.0001).

synapsesocial.com/papers/6a7dbe237096e04f9ca1469fhttps://doi.org/10.3343/alm.2017.37.2.137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analytic and Clinical Utility of a Next-Generation, Highly Sensitive Cardiac Troponin I Assay for Early Detection of Myocardial Injury2009 · 164 citations
  2. 2Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population2010 · 1,108 citations
  3. 3ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)2011 · 3,095 citations
  4. 4Task force on the management of chest pain2002 · 288 citations
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