Population
124 families ascertained by an index case with aortic valve stenosis, coarctation of the aorta, or…
Design
Cross-sectional
Authors
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May support family screening in LVOTO; leaves open prospective validation of heritability before practice change.
LVOTO malformations demonstrate high heritability and a significantly elevated relative risk among first-degree relatives, supporting an oligogenic inheritance pattern and highlighting the clinical utility of screening asymptomatic family members.
McBride et al. (2005) studied this question.
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