August 1, 1998Arthritis & Rheumatism

Frequent occurrence of anti-tRNAHis autoantibodies that recognize a conformational epitope in sera of patients with myositis

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Population

167 myositis sera

Design

Cross-sectional

Authors

RBRick BrouwerZiekenhuis Groep Twente WEWilma Vree EgbertsRadboud University Nijmegen PJPeter H. JongenRadboud University Nijmegen

Discussion

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Implication

Does not support routine tRNA(His) testing in myositis; leaves open prognostic relevance pending prospective validation.

Structured PICO

Population

167 myositis sera

Outcome

Incidence of autoantibodies directed to deproteinized tRNA(His) and determination of the major B cell epitope

A significant proportion of anti-Jo-1 positive myositis patients have autoantibodies against tRNA(His), recognizing a conformational epitope dependent on proper RNA folding.

Cite This Study

Brouwer et al. (1998) studied this question.

synapsesocial.com/papers/6a7dbeb28b7e38892f15091c https://doi.org/10.1002/1529-0131(199808)41:8<1428::aid-art12>3.0.co;2-j

View Full Paper

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Frequent occurrence of anti-tRNAHis autoantibodies that recognize a conformational epitope in sera of patients with myositis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Frequent occurrence of anti-tRNAHis autoantibodies that recognize a conformational epitope in sera of patients with myositis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider