Key result
Guideline-directed medical therapy was initiated in 51.2% of acute heart failure patients during hospitalization, but early discontinuation was common and 12-month target dose achievement was low.
Despite the proven benefits of guideline-directed medical therapy in heart failure, real-world implementation shows significant gaps with high rates of early discontinuation and low achievement of target doses, highlighting the need for personalized adherence strategies.
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Meixiang Xiang (2025) conducted an editorial in Acute heart failure (n=791,917). Guideline-directed medical therapy (GDMT) was evaluated on Doses and patterns of up-titration or discontinuation of GDMT following hospitalization. Guideline-directed medical therapy was initiated in 51.2% of acute heart failure patients during hospitalization, but early discontinuation was common and 12-month target dose achievement was low.
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