Key result
Carriers of APOC3 variant alleles had a significantly higher prevalence of nonalcoholic fatty liver disease compared with wild-type homozygotes (38% vs 0%; P<0.001).
Why the study?
Are APOC3 variant alleles associated with nonalcoholic fatty liver disease and insulin resistance in healthy men?
Population
258 healthy men, comprising an initial cohort of 95 Asian Indian men and a validation cohort of 163…
Comparison
Carriers of APOC3 variant alleles vs Wild-type homozygotes for APOC3
Design
Cross-sectional
Authors
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APOC3 variants were associated with higher NAFLD prevalence; hypothesis-generating and should not yet change practice or screening.
Observational (n=258)
Are APOC3 variant alleles associated with nonalcoholic fatty liver disease and insulin resistance in healthy men?
Absolute Event Rate: 38% vs 0%
p-value: p=<0.001
APOC3 gene variants (C-482T and T-455C) are strongly associated with nonalcoholic fatty liver disease, hypertriglyceridemia, and insulin resistance in healthy men.
Petersen et al. (2010) conducted an observational in Nonalcoholic fatty liver disease (n=258). APOC3 variant alleles (C-482T, T-455C, or both) vs. Wild-type homozygotes was evaluated on Prevalence of nonalcoholic fatty liver disease (p=<0.001). Carriers of APOC3 variant alleles had a significantly higher prevalence of nonalcoholic fatty liver disease compared with wild-type homozygotes (38% vs 0%; P<0.001).
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