Key result
Genetic variants in IL15, NPY2R, and NPY5R were strongly associated with left ventricular phenotypes in black hypertensive siblings (P<0.005), with suggestive associations in whites (P<0.05).
Observational (n=885)
Yes
p-value: p=<0.005
Specific genetic variants on chromosome 4, including in NPY and IL15 genes, are associated with left ventricular hypertrophy traits in hypertensive individuals.
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Does not support genetic testing in hypertension; leaves open ancestry-specific roles for IL15/NPY variants in LV phenotypes.
Arnett et al. (2009) conducted an observational in Hypertension and left ventricular hypertrophy (n=885). Genetic variants in candidate genes (NPY1R, NPY2R, NPY5R, SFRP2, CPE, IL15, EDNRA) was evaluated on Left ventricular mass index, relative wall thickness (RWT), and aortic root diameter (ARD) (p=<0.005). Genetic variants in IL15, NPY2R, and NPY5R were strongly associated with left ventricular phenotypes in black hypertensive siblings (P<0.005), with suggestive associations in whites (P<0.05).