In a rabbit model, ADP released from red cells appears to be the most potent stimulator for haemostatic plug formation in the mesenteric microcirculation.
Warrants no change in clinical practice; leaves open ADP's translational role in human microvascular hemostasis.
The local stimulation and inhibition of haemostatic plug formation was studied by local infusion and superfusion of different agents - ADP, thrombin, adenosine, heparin, prostaglandin E1 (PGE1) and laster injury. ADP and laser injury shortened venular haemostatic plug formation time whereas adenosine in the superfusate and PGE1 prolonged it. Thrombin infusion had no effect but thrombin in the superfusate significantly stabilised the haemostatic plugs. It is suggested that ADP released from red cells is the most potent stimulator for haemostatic plug formation in the rabbit mesenteric microcirculation.
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Bergqvist et al. (1976) studied this question.
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