August 23, 1988Proceedings of the Royal Society B Biological Sciences

Evidence for the dependence of arterial haemostasis on ADP

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Population

Anaesthetized rats

Design

Preclinical

Authors

MMMyra O. McClureAmgen (United States)AKAmit KakkarAlbert Einstein College of Medicine NCNoel J. CusackUniversity of London

Discussion

Member takes

Implication

ADP inhibition prolongs bleeding in animal arterial models; leaves open translation to human antiplatelet strategies.

Structured PICO

Population

Anaesthetized rats

Intervention

Infusion of apyrase (nucleotide-dephosphorylating enzyme) or ADP-receptor antagonists (ATP, AMP-PCP, or 2-MeS-AMP-PCP) into mesenteric arterial blood

Outcome

Duration of primary haemorrhage (standardized bleeding times from punctures of small mesenteric arteries)surrogate

This preclinical study demonstrates that local ADP release and formation at sites of vascular injury contribute significantly to arterial haemostasis by accelerating platelet aggregation.

Cite This Study

McClure et al. (1988) studied this question.

synapsesocial.com/papers/6a8bef2a77493d51bfdef388 https://doi.org/10.1098/rspb.1988.0047

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Evidence for the dependence of arterial haemostasis on ADP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for the dependence of arterial haemostasis on ADP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider