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January 1, 2006Frontiers in bioscienceOpen Access

The role of ADP receptors in platelet function

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Population

Basic science and preclinical models studying the role of ADP receptors in platelet function and hemostasis.

Design

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Authors

SMSwaminathan MurugappanUniversity of Minnesota

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Implication

May inform selective anti-thrombotic drug design; leaves open which ADP receptor targets optimize efficacy and safety in trials.

Structured PICO

P
Population
Basic science and preclinical models (including knockout mice and human platelets) studying the role of ADP receptors (P2Y1, P2Y12, P2X1) in platelet function and hemostasis.

Understanding the distinct functions of P2Y1, P2Y12, and P2X1 receptors in ADP-mediated platelet activation is crucial for developing targeted and safe anti-thrombotic therapies.

Cite This Study

Swaminathan Murugappan (2006) studied this question.

synapsesocial.com/papers/6a7624a9756843cacbb24deehttps://doi.org/10.2741/1939
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of P2Y1 purinoceptor in ADP‐induced platelet activation1998 · 195 citations
  2. 2Emerging roles for P2X<sub>1</sub>receptors in platelet activation2004 · 74 citations
  3. 3Potentiation of Thromboxane A2-induced Platelet Secretion by Gi Signaling through the Phosphoinositide-3 Kinase Pathway2001 · 92 citations
  4. 4Role of G protein–gated inwardly rectifying potassium channels in P2Y12 receptor–mediated platelet functional responses2004 · 64 citations
  5. 5Signaling through Gi Family Members in Platelets2002 · 150 citations