Key result
P2 receptor subtypes (P2Y1, P2Y12, and P2X1) mediate distinct aspects of ADP-induced platelet activation, including shape change and granule release.
Population
Platelets (basic science review)
Design
Review
Authors
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May guide receptor-specific antiplatelet development; leaves open clinical outcome benefits versus broad inhibition.
This review clarifies the distinct roles of P2Y1, P2Y12, and P2X1 receptors in ADP-mediated platelet activation, providing a foundational understanding for antiplatelet therapies.
S.P. Kunapuli (2002) conducted a review in Hemostasis and thrombosis. P2 receptors (P2Y1, P2Y12, P2X1) was evaluated. P2 receptor subtypes (P2Y1, P2Y12, and P2X1) mediate distinct aspects of ADP-induced platelet activation, including shape change and granule release.
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