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Validates P2Y12 inhibition in current regimens; leaves open refinement of next-generation agents in targeted populations.
ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.
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Kim et al. (2011) studied this question.
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